ADC Scientist, Early Oncology Discovery

Gaithersburg, Maryland

Posted in Pharmaceuticals
about 1 month ago

This job has expired.

Job Description

ADC Scientist, Early Oncology Discovery

Location: Gaithersburg, MD

At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.
AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and hematological cancers.
We are seeking a highly motivated and independent Scientist with experience in cancer biology with a track record of scientific excellence in in vitro cancer modelling, to join our antibody-drug conjugates (ADCs) team in Gaithersburg, MD USA. As a Scientist you will be a key member of a team focused on delivering all aspects of pharmacology support. You will bring your theoretical and practical expertise to establish assay systems and deliver datasets that will have direct impact on the drug discovery process and pipeline.

Main Duties and Responsibilities

Working in this laboratory-based position within the Early Oncology ADC Platform Development Team, you will develop, design, conduct and analyze in vitro experiments to assist in the development of our next generation ADC therapeutics. Specifically, you will help evaluate how changes to our antibodies, linkers and warheads can optimize the therapeutic index of our ADCs. You will be expected to support cross-functional teams and work collaboratively with project managers to ensure the timely generation and dissemination of critical program data. As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in the ADC field, tumor biology and cancer modelling and have a genuine passion for this field of research. The candidate may also be conduct ex vivo analyses of our ADCs based on interest and experience.
Essential Requirements

  • Bachelor degree with >5 years of research experience in cancer/cell biology, or a Master's degree in cancer/cell biology. Prior experience in the biopharmaceutical industry preferable.
  • Experience with routine cell culture, particularly culture of tumor cells
·Experience assessing in vitro activity of ADCs via assays to determine binding and internalization (e.g. flow cytometry) and cytotoxicity (e.g. CellTiterGlo assays)
  • Experience with flow cytometry and relevant analysis software (ex. FlowJo)
  • Works independently with minimal supervision to conduct experiments
  • Excellent communication and presentation skills to report data in a clear and concise manner, with a clear understanding of its implications within the overall context of drug discovery
  • Strong interpersonal and collaboration skills together with evidence of delivery in a team-oriented, collaborative environment
  • A proven track record of productivity; contributions to scientific publications in peer-reviewed journals preferred

Desirable Requirements·Knowledge of the industrial drug discovery process
  • Experience in conducting tumor immunology in vitro assays including
    • Assays to assess immunological output, e.g. ELISA, western blotting, etc.
    • Antibody-dependent cellular cytotoxicity (ADCC) assays including co-culture assays evaluating immune cells (e.g. PBMCs) and tumor cells
    • Ex vivo studies utilizing cell-based xenografts, patient-derived xenografts, and/or immuno-competent syngeneic mouse tumor models

AstraZeneca is an Equal Opportunity Employer and does not discriminate on the basis of race, color, religion, gender, age, national origin, disability, veteran status, or any other characteristic protected by federal, state or local law.

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