Are you a passionate Scientist thriving to make a true impact on patients' lives? The vision ofAstraZeneca Early Respiratory & Immunology is centered on delivering life-changing products that advance world health and help fight and cure disease. Here, you'll have the opportunity to make a difference in people's lives every day. Are you ready to join us and see what science can do?
At AstraZeneca, we believe in the potential of our people and you'll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.
We are seeking a highly motivated Scientist II researcher to join the Asthma Early Respiratory & Immunology research group in Gaithersburg, MD to work on an independent research project focused on investigating the pathogenesis of skin diseases including atopic dermatitis, and the identification of novel targets. Within our Gaithersburg based research team, we are seeking an experienced research Scientist with a strong understanding of dermal biology and experience with primary model systems. In this role, you would be expected to demonstrate an exceptionally high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have expertise in modeling skin disease using primary cell cultures and co-cultures, and an ability to apply this experience to an understanding of the basic mechanisms of human skin pathologies. A good understanding of skin structure and the crosstalk between skin cells is essential.
What you'll do
This job is a lab-based research role, and you will have a significant opportunity to drive the direction of the work. The work will be predominantly human in vitro systems, working with primary and disease tissue-derived cells, although knowledge and experience of in vivo science is a bonus. A background in human skin diseases including atopic dermatitis and translational approaches to understand basic biological mechanisms in disease is needed.
Essential for the role
- You will focus your research on characterizing novel biology pathways in skin diseases such as atopic dermatitis to aid target validation and drug projects.
- The role will be based in Gaithersburg within AstraZeneca's state-of-the-art laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives.
- You will collaborate with scientists from a variety of functional teams in Gaithersburg and with our sites in Cambridge, UK, and Gothenburg, Sweden.
- You will benefit from daily interaction and collaboration with highly accomplished scientists and the position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of research and drug discovery.
- You will have the opportunity to mentor junior scientists
- Encouragement and support will be provided to help you develop specialist knowledge and skillsets.
- Publication of your work in high impact journals.
- A Ph.D. in Immunology, Biochemistry or a closely related field with experience in industry
- A deep understanding of skin structure and pathogenesis of at least one skin disease such as atopic dermatitis
- Technical expertise in primary models of human skin disease
- Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project.
- Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression; ELISA, Western blot and flow cytometry
- Strong written and oral communication skills and the ability to critically analyze data sets.
- Expertise with primary cell culture/co-culture of skin cells
- Demonstrated ability to run collaborative efforts and utilize external resources to find the most effective solutions to deliver high-quality science, translatable to human disease.
- The ability to develop in vitro and ex-vivo models to understand mechanisms important in skin pathogenesis
- Excellent publication record (project is expected to yield publication of scientific results in peer-reviewed journals) and the ability to apply current scientific literature to projects.
- In vivo skills are a strong plus, association with in vivo models of skin disease is a plus but not essential.
- Experience and ability in basic cell culture imaging techniques is highly desirable
- Effective contributing to collaborative projects involving cross-disciplinary and global teams.
- Experience with mentoring students at the undergraduate and Ph.D. level.
- Scientific creativity and ability to drive own research ideas to a successful conclusion, demonstrated by strong publication record or project progression
- Drive for constant personal development and increasing skill base.
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods and bringing unexpected teams together. Interested? Come and join our journey.So, what's next!
If you are ready to make a difference - apply today, and we'll make it happen together!Where can I find out more?
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Ensuring the health and wellbeing of our employees and the patients on our clinical trials is of paramount importance to us at AstraZeneca. We fully support and commend the vital role physicians are undertaking during the COVID-19 pandemic. We will continue to recruit open physician vacancies, making use of digital capabilities to ensure we can continue to recruit great talent, but we want you to be aware that we are happy to discuss postponing start dates, releasing you for voluntary/ paid clinical work or similar activities during this time. We thank you in advance for all you are doing for patients in these challenging times.