Co-Op, Preclinical Pharmacology
AstraZeneca

Job Info

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This is what you will do:

Alexion AstraZeneca rare disease genomics medicine department is seeking a highly motivated Co-op to join our preclinical pharmacology group. This position will drive pipeline projects through vector evaluation, target validation, and candidate selection in vitro, ex vivo, and in vivo studies. We offer 1:1 training and provide individuals a great opportunity to learn and grow, including but not limited to preclinical pharmacology research, organization skills, working with flexibility, and the ability to thrive in an efficient, highly interactive, goal-oriented team environment.

You will be responsible for:

• Perform in vitro, ex vivo, and in vivo studies to understand the mechanisms of action.
  
• Sample processing includes but is not limited to cell and tissue DNA, RNA extractions for NGS, and barcode downstream analysis.
  
• Assist in construct design, molecular cloning, and vector characterization.
  
• Perform biochemical assay (e.g., ELISA, Western Blot, enzymatic kinetics) of biological and tissue specimens from preclinical studies.
  
• Perform analytical tests such as qPCR and ddPCR for characterization of rAAV vectors, etc.
  
• Perform indel analysis for gene-editing programs.
  
• Perform efficacy studies to support the preclinical development of genomic medicine candidates.
  
• Participate in project meetings and conduct work reports.
  
• Keep accurate records of research activities and experimental details.
  

You will need to have:

• Hands-on experience in a biology lab.
  
• Experience in molecular biology techniques (cloning, ELISA, Western blot, PCR/qPCR/ddPCR, etc.) is strongly desired.
  

• Proficiency in basic software (e.g., MS Office) and strong data analysis skills.
  
• Ability to work independently and as part of a team with confidence.
  
• Strong verbal communication skills and ability to excel in a fast-paced environment.
  

We would prefer for you to have:

• 1 year experience in the biology lab.
  
• AAV-related biology knowledge.
  
• Gene and cell therapy knowledge
  

• The duties of this role are generally conducted in an lab environment. As is typical of a lab-based role, employees must be able, with or without an accommodation to: lift/carry 15/30 pounds unassisted/assisted; work comfortably in a controlled environment with and around biological, infectious, and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.
  

In-person statement for 4 days in the office:
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of four days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Vaccine Requirement:

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

This job has expired.