Have a degree in Toxicology or related field with experience in conducting or supervising in vitro cytotoxicity and genotoxicity studies? If so, we invite you to be a part of Altrias 10-year Harm Reduction vision and journey to responsibly lead the transition of adult smokers to a non-combustible future.
We are hiring an In Vitro Toxicologist to join our Biological Sciences Insights (BSI) group in Richmond, VA. or we are open to remote work arrangements. The selected candidate will use their scientific and technical expertise to design, implement, and report toxicological outcomes from preclinical (in vitro) studies to aid in regulatory submission, product development and foundational research.
Specific accountabilities include:
Subject matter expertise in preclinical (in vitro) testing of test materials (individual and mixtures; tobacco and nicotine products), under the applicable principles of Good Laboratory Practices (GLP) and 3Rs, in support of overall risk assessment
Serve as Sponsor Representative, planning, monitoring, and managing studies conducted at external Contract Research Organizations (CROs)
o Key tasks: prepare Statement of Work, review proposals, oversee study related budget, finalize study design/protocols, and monitor deliverables to completion (to reporting and archiving)
Identify forward-looking in vitro capability gaps; screen and qualify candidate external CROs
May require occasional travel (10-20%) to CRO site for lab selection, inspection, or study monitoring
Preclinical lead for regulatory toxicology testing; scope, communicate findings, and write preclinical sections of regulatory dossiers; peer-reviewed publication
Attend and/or present at scientific meetings to represent companys work or to augment job skills.
Monitor emerging Tox21 assessment tools (e.g., in vitro- and in silico-based) for its relevance in screening materials or products; communicate with external and internal partners as part of foundational research
Bachelors or preferably an advanced degree (MSc or PhD) in toxicology, pharmacology, biochemistry or related field; DABT is a plus
Five or more years of hands-on experience in conducting regulatory (e.g., OECD) in vitro genotoxicity and cytotoxicity studies (Three or more years of experience will be acceptable for candidates with advanced degrees).
Comprehensive understanding of Data Integrity and GLP; working knowledge of quality assurance inspection process at CROs (as study director or study monitor)
Excellent project scoping and management skills; attention to detail and ability to meet deliverables under a highly dynamic environment
Excellent written and oral communication skills; Strong interpersonal and problem-solving skills; work effectively both independently and as a team
Additional hands-on experiences with primary cells and organotypic tissues or organs; conducting mechanistic toxicity studies; high-content or high-throughput screening assays (e.g., Tox 21) and air-liquid-interface in vitro testing, as a plus.
In addition, we offer an excellent compensation package including a competitive base salary, comprehensive health/vision/dental insurance, participation in our deferred profit sharing and incentive compensation programs as well as a relocation assistance package.
Posted about 2 hours ago
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