Lead Computational Chemist - Oncology R&D

Waltham, Massachusetts

Posted in Pharmaceuticals

This job has expired.

Job Info

Lead Computational Chemist - Oncology R&D

Permanent Opportunity

Boston - US

At AstraZeneca, we turn ideas into life-changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We're passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life!

AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer and to ultimately eliminate cancer as a cause of death!

To succeed in this vision, AstraZeneca are seeking a computational chemist for our Oncology medicinal chemistry department based in Waltham, Massachusetts. The successful candidate will be a professional computational chemist, with a passion for drug discovery and experience of working in drug discovery project teams within a biotech or pharmaceutical setting. You will be working closely with an established, transnational team of computational chemists within AstraZeneca working on oncology drug discovery projects across a range of modalities and will have access to state-of-the-art computational methods, such as our FEP and AI platforms, and excellent lead generation capabilities.

Does this sound like you? if so...we are keen to speak with you.

Key responsibilities

As a leading member of the medicinal chemistry design team, you will be responsible for:

Setting and delivering on computational and medicinal chemistry strategies to impact project success at all stages from drug target identification through to clinical candidate nomination.

Working with a high degree of independence, you will carry out structure- and ligand-based design and data analysis, extracting insight from large proprietary structural biology and SAR data sets; your contributions to molecular design will be expected to result in inventorship on patent applications.

You will work closely with scientists from other disciplines including structural biology, biophysics, ADME/DMPK and safety sciences as part of the wider drug discovery project team, and will present your work regularly to peers and senior partners. Depending on experience and interest, you might also function as the lead chemist for a drug discovery project.

At AstraZeneca, we value scientific innovation. Maintaining an awareness of the current state-of-the art, you will identify promising new computational methodologies or technologies that could benefit drug discovery, and will develop and implement these through internal or external collaborations, sharing best practice across AstraZeneca. You will be expected to publish your work regularly in high quality scientific journals and at national and international conferences.

You'll have the opportunity to build academic collaborations and to supervise graduate scientists and postdocs, as well as to mentor colleagues. The scope for personal development is vast.


  • Ph.D. degree in computational chemistry (or similar) with greater than 5 years of experience working as a computational chemist on drug discovery projects in a Pharmaceutical or Biotech setting, or B.Sc./M.Sc with 10+ years of experience
  • Broad experience in protein structure and dynamics, structure- and ligand-based design, data analysis and property prediction
  • A passion for drug discovery and an excellent understanding of medicinal chemistry concepts
  • Innovative problem-solver, with a track record of impacting drug project delivery
  • Scientific and project impact exemplified by high quality scientific publications
  • Strong oral and written communication skills, team-working and time-management skills

You will receive a generous remuneration and be eligible for highly competitive flexible benefits.

If you are passionate about the possibilities of science to make a difference and are ready to discover what you can do, then apply today.

About The Site

The Waltham R&D site is home to our small-molecule oncology research in North America and is situated within a biopharma cluster of academic research institutions, medical centers, pharmaceutical companies and biotech startups. The Boston region is consistently ranked #1 globally for biotech research, investment, talent recruitment and lab space.

The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists and experts working in different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking, with charging stations for electric vehicles, is available, as is shuttle service to local transportation hubs.

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.

AstraZeneca has taken critical steps to protecting colleagues, loved ones, and patients from COVID-19 and its variants. COVID-19 vaccination is required for all US employees, and weekly PCR COVID-19 testing is required for those who are unvaccinated or have an approved accommodation.

This job has expired.

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