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The Diabetes Research Institute of the University of Miami has an exciting opportunity for a Full-time Postdoctoral Associate. The Post Doctoral Associate performs scientific research and studies under the supervision of managing staff. Moreover, the Post Doctoral Associate promotes institutional recognition through literal contributions to the scientific community. The main lines of research in the Beta Cell Regeneration Lab revolve around the development of regenerative strategies for type 1 diabetes, including stem cell differentiation into insulin-producing β-cells and islet regeneration. In particular, our current research is focused on the induction of human pancreatic ductal BMP-responsive progenitor cells, which we have identified and characterized by lineage tracing (Klein et al ., Diabetes , 2015; Qadir et al. , Cell Reports , 2018); single-cell RNAseq and transplantation of sorted populations (Qadir et al ., PNAS , 2020); and organotypic culture (human pancreatic slices) techniques (Qadir et al. , Nature Comms , 2020). Our seminal contribution to the development of the latter has enabled for the first time the real-time monitoring of β-cell regeneration in an in vitro setting that resembles the native organ. Our research pipeline is expected to help us realize the full potential of single-cell transcriptomics to unveil dynamic biological processes, model human pancreatic disease, and, ultimately, enable the development of regenerative therapies for diabetes.
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