Senior Scientist
AstraZeneca

Job Info

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Senior Scientist

Do you have a passion for science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the place for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the group:

The Cell Culture and Fermentation Sciences Group is accountable for cell line development, process development, and process characterization. This group assists in the scale up and technical transfer of processes to different clinical and commercial sites and also supports manufacturing deviations and regulatory submissions as needed. The team will work with bioreactors and genetically modified Chinese hamster ovary cells to produce new drugs to support the pre-clinical portfolio and clinical development with key reagent production.

Main Duties & Responsibilities:

• Generate the biological material for preclinical studies, including non-GLP and research studies, using mammalian cells at bioreactor operating scales of up to 36L

• Generate plasmid DNA for transient transfections, as well as develop process improvements for plasmid DNA production

• Optimize the transient transfection technology for production of therapeutic proteins in mammalian cells

• Develop perfusion technology for transient transfection production

• Develop improved chemically-defined media

• Makes detailed observations, analyzes data, and interprets results. Demonstrates scientific rigor in assessing own data and that of others.

Education & Experience Requirements:

Education: Bachelor's, Master's, or PhD in Chemical/Biochemical Engineering or a related field

Experience: Bachelor's and 10+ years, Master's and 8+ years, or PhD and 2+ years of relevant industry experience

Required Skills:

• Experience in a laboratory environment using mammalian cell culture

• Solid understanding of biochemical engineering concepts and biochemical pathways

• Responsible for a wide variety of recombinant protein in mammalian cell lines from stable pools of cells and transient transfections in bioreactors.

• Responsible for suitable processes for small and large-scale recombinant protein production, including feed strategies.

• Responsible for in-house technology for rapid production of protein reagents from transient transfections at multi-liter scale.

• Design and execute experiments as well as troubleshooting.

Desired Skills:

• Plasmid DNA production and process optimization

• Bioreactor operation knowledge of design of experiment (DOE)

• Analysis of data using statistical analysis software such as JMP

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential.

Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods, and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours.

Where can I find out more?

Check out our landing page for more information on our BPD group https://careers.astrazeneca.com/bpd

Our social media:

Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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