Senior Scientist - Bioinformatics, Oncology R&D
AstraZeneca

Waltham, Massachusetts

Posted in Pharmaceuticals


This job has expired.

Job Info


AstraZeneca is a global, science-driven biopharmaceutical company. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients. In AstraZeneca Oncology, our goal is to be at the forefront of developing the next generation of cancer therapies.

In addition to our passion for the discovery of innovative new medicines, we understand the importance of flexibility in our work-life environment and we offer a wide variety of benefits, services and programs that provide our employees the resources they need to pursue not only their work goals but also their life goals. We are dedicated to building strong research teams that embrace the diversity of talents of team members and allow the larger group to grow and learn together to accomplish our collective goal to improve human health.

About AstraZeneca in Waltham, MA

The Waltham R&D site focuses on our small-molecule oncology research in North America, and is situated within a biopharma cluster of research institutions, medical centers, pharmaceutical companies and startups. The Boston region is consistently ranked #1 globally for research, investment, talent recruitment and lab space.

The campus, also known as the Boston BioHub, is one of the largest and most dynamic life-science research hubs in the region. It is home to more than 800 scientists working in nine different pharmaceutical and biotech companies. The site is also home to the AstraZeneca Incubator, a program that helps emerging companies advance novel and innovative healthcare solutions to meet the needs of patients. Plenty of free parking, with charging stations now available for electric vehicles, and shuttle service to local transportation hubs.

Summary of the Group

The Early Computational Oncology team works with our oncology drug project teams throughout the research and early development pipeline, from new target discovery to translational medicine and clinical trials. Our global group aligns its activities to AstraZeneca's primary areas of focus in Oncology: tumor drivers & resistance, DNA damage response, immuno-oncology, epigenetics, cell therapies and antibody-drug conjugates. We deliver data-driven, actionable insights through the application of computational science to all areas of Oncology portfolio. The group has substantial expertise and a renowned track record in bioinformatics and data science, undertaking both portfolio applied informatics research and the development of innovative capabilities. Our team is expanding to meet the growing Oncology portfolio and the challenges of pre-clinical and clinical big data generation initiatives including DNA sequencing, single-cell and bulk expression, epigenetics, proteomics and CRISPR.

Main Duties & Responsibilities

We are looking to add a passionate, motivated Senior Scientist with a strong background and experience in tumor driver and resistance biology, ctDNA analysis and/or cancer genomics.

  • Develop and perform innovative computational analyses of multi-modal data from clinical trial samples in AZ's key targeted assets
  • Be an integral part of drug project and clinical teams to understand their scientific and technical challenges and proactively impact these using bioinformatics
  • Apply data and knowledge analytics to deliver actionable insights driving discovery and development of the next generation of cancer medicines
  • Discover new insights from complex biological data via innovative analysis or visualization
  • Work with internal groups, collaborators, and external companies to influence generation of data assets and analytical methods
  • Build internal analytical capabilities to enable peers and bench scientists to explore and understand complex data
  • Positively contribute to the field of oncology via presentations at conferences and publications in high impact journals

Education & Experience Requirements

PhD in Bioinformatics, Computer Science, Engineering or similar discipline with related technical expertise in either bioinformatics, computational biology, biostatistics, mathematical modelling, data science or knowledge engineering.

Required Skills
  • Deep understanding of the molecular mechanisms driving cancer and/or ctDNA biology
  • R and/or Python programming and visualization expertise, experience with Unix environment and high-performance computing environments, AWS
  • Skilled in effective communication of complex data to a non-expert
  • Enthusiasm and persistence in the application of analytical methods to complex biological problems
  • Capability of successfully managing multiple simultaneous projects
  • Working effectively within cross-disciplinary science teams
  • Experience contributing to the research community through publication, conferences, and code sharing

Desired Skills
  • Working experience with machine learning, artificial-intelligence, Bayesian analytics or other non-traditional approaches to model biological data
  • Strong publication record
  • Strong established network within external bioinformatics and oncology communities

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next!

Are you already envisioning yourself joining our team? Good, because we can't wait to hear from you!

If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.

Closing Date: September 23, 2022

Competitive remuneration and benefits apply

We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We align with all applicable laws and regulations on inclusivity in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.


This job has expired.

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